AB0397 DISEASE ACTIVITY OF RHEUMATOID ARTHRITIS WERE SIGNIFICANTLY DECREASED BY SWITCHING JAK INHIBITOR TO ANOTHER JAK INHIBITOR

Background With the availability of multiple Jak inhibitors (JAKi) for treatment, patients with RA who have had inadequate response to conventional therapies, including biologics, can now achieve favorable outcomes such as remission and low disease activity. However, it is also true that no single JAKi therapy effective all RA. Some treatment guidelines recommend a switch strategy from current other or biologics in [1]. There insufficient evidence support efficacy switching another (JAKi-IR). Objectives The aim this study clarify effectiveness controlling activity by cases JAKi-IR analyze effect on serum cytokines related pathogenesis Methods switched during between September 2017 January 2022 were included retrospective study. clinical characteristics collected their medical records. was assessed changes composite measure scores activity, DAS28-CRP, SDAI, CDAI, at 4 12 weeks after switch. In addition, associated (IL-6, TNF-α) measured analyzed ELISA (Simple Plex, Protein Simple). Results Twenty-nine received analysis. are shown Table 1. All receiving due biologics. control 3 (10%) achieved temporary remission. Baseline 29 enrolled Clinical n=29 Age 57 [48.0-66.0] Sex (F/M) 22/7 (75.9) Disease duration, years 13 [8.6-18.8] RF positive 26 (89.7) ACPA positive, (n=22) 20(90.0) Concomitant medications Methotrexate, dose(mg/week) 10 (34.5), 8.0 [6.0-10.5] Corticosteroid, dose(mg/day) 17 (59.0), 4.0 [2.0-5.0] DAS28-CRP 3.77 [3.2-4.6] SDAI 15.5 [9.8-21.1] CDAI 14.5 [9.5-20.0] Patient global assessment (mm) 40 [25-58] Provider 32 [15-40] CRP (mg/dl) 0.9 [0.1-1.7] TJC/SJC [2-5], 2[2-5] Date n (%) median [IQR]. Figure 1 shows category. Evaluation using showed 65% immediate goal switch, 69% maintained weeks. observed 17% 31% weeks, demonstrating strategy. measures Changes before patients. Regardless type JAKi, IL-6 decreased most 12weeks (average change IL-6: -27.25pg/ml). trend TNF- acti（average TNF-ed change）. clear association these two Conclusion index about 60% one goals, up This did not appear be JAKi. effects biologic differed References [1]György Nagy, et al. EULAR points consider management difficult-to-treat rheumatoid arthritis. Annals Rheumatic Diseases 2022;81:20-33. Disclosure Interests None declared